PPIs Cause Brain and Kidney Damage

I had to reread this and I still had some doubts, but science cannot always be that wrong. But apparently, it is science that is clearly pointing at proton pump inhibitors (PPIs) in increasing the risk of Alzheimer’s by 50 percent and Kidney disease by up to 50 percent. It is a fact that stomach acid drugs have become conventional medicine's wrongheaded answer to stomach pain and acid reflux.

Again our scientists aren't knowledgeable about what causes acid reflux, but a leading hypothesis is that it’s caused by a stomach environment that is not acidic enough. The lack of acid in the stomach short-circuits the signal needed to close the lower esophageal sphincter (LES). Stomach pain may also be caused by a lack of stomach acid. It sounds counterintuitive, but the lack of acid leads to poor digestion, causing undigested food to ferment in the gut. This leads to painful intestinal gas and other symptoms of “bad bacteria” (such as helicobacter bacteria) taking hold. Here, too, more acid, not less, will help.

Despite this evidence, conventional medicine gives us proton pump inhibitors (PPIs) to treat stomach pain and acid reflux, which work by eliminating acid production, thus making the problem even worse.

The bad news doesn’t stop there. Recent studies have revealed a frightening spectrum of side effects caused by acid blockers:

• A large study published in JAMA Neurology found PPIs to be linked with dementia and Alzheimer’s disease. The study found that regular use of PPIs increased the risk for dementia by as much as 52% compared with nonusers.
• Two new studies have linked acid blockers with chronic kidney disease. The increase in risk is cited as 20–50%.
• Another study found that PPIs may raise the risk of heart attack by 15–20%. Other studies have shown that PPIs damage the lining of blood vessels and thus promote cardiovascular events.

The link with pneumonia and other infectious diseases was established years ago. This may be because acid is a barrier to infectious organisms getting inside your body.

Stomach acid helps digest food and too little stomach acid can lead to nutrient deficiencies (since it is harder for the body to extract minerals and vitamins from food) and food poisoning. Reduced calcium absorption, for instance, leaves people who regularly take PPIs susceptible to bone fractures.

It can also be hard to stop taking PPIs once started. When patients stop taking them, fermentation can cause pain. It may also be hard to re-establish the ability to produce acid.

Given these dangers, why do doctors continue to suggest these drugs to their patients? As always, it is instructive to follow the money. Blockbuster drugs in this class such as Prevacid, Prilosec, and Nexium bring in billions of dollars each year.

The good news is that stomach pain can be managed without using these dangerous drugs. Restoring stomach acid with hydrochloric acid supplements both helps the stomach signal the pyloric valve to close and also helps control the helicobacter bacteria. Lifestyle changes can also help reduce stomach pain and acid reflux, such as losing weight and eating a healthy diet.