Vitamin D
Overview
Many of us are deficient in certain
nutrients and our doctors do not test us as we age. Some of us do
have sufficient quantities in our diets and then take supplements,
which may give us an oversupply. Your doctor should test for all of
these (that have testing available) before you run out and buy
supplements. You may not need them as part of your diet because you
are already obtaining sufficient intake from your diet.
I would be remiss if I did not give you
a warning about not overcompensating and ingesting too much of some
of these nutrients as there are some medical concerns with toxicity
and conflicts with certain prescription medications. More is often
not better and can be fatal with some supplements and herbal
supplements.
Vitamin D is one large misnomer as it
is a hormone, but this is now commonly accepted and will likely never
be changed. It is the one that most people will have a difficult
time in overdosing, but it has happened.
Tests
This is to inform you that the newer
Vitamin D blood tests are over 40 percent unreliable and you need to
make sure that the tests are not used. Please read
this article in
WebMD. Older testing procedures are the better bet.
Recommended Daily Allowance
The current RDA for vitamin D is being
revised, and some experts suggest that adults should take at least
2000 IU of vitamin D daily. I personally use 3000 IU of Vitamin D3
daily and some that I know take as high as 10,000 IU.
Recommended dietary allowances
currently for vitamin D are listed below. Seniors and people who don't get exposed too much sunlight may need to take supplements. Seniors
may be at risk of developing vitamin D deficiency because, as we age,
the body does not make as much vitamin D from sunlight, and it has a
harder time converting vitamin D into a form it can use.
If you are concerned about your vitamin
D levels, ask your doctor whether you should take a supplement, and
how much.
Pediatric
1. Infants birth to 12 months: 400 IU (adequate intake)
2. Children 1 - 18 years: 600 IU (recommended dietary allowance)
Note: The American Academy of
Pediatrics (AAP) recommends 400 IU of vitamin D daily for breastfed
infants until they are weaned and drinking at least 1 liter of whole
milk or formula fortified with vitamin D. The AAP also recommends
that children and teens who drink less than 1 liter of milk a day
take 400 IU of vitamin D.
Ask your doctor before giving a vitamin
D supplement to a child.
Adult
1. 19 - 50 years: 600 IU (recommended dietary allowance)
2. 70 years and older: 800 IU (recommended dietary allowance)
3. Pregnant and breastfeeding females: 600 IU (recommended dietary
allowance)
Food Sources
There are two dietary forms of vitamin
D:
1. Cholecalciferol - D3
2. Ergocalciferol - D2
These are naturally found in foods and
are added to milk. Not all yogurt and cheese are fortified with
vitamin D. Food sources of vitamin D include:
1. Cod liver oil (best source). Cod liver oil often contains very
high levels of vitamin A, which can be toxic over time. Ask your
health care provider about this source of vitamin D.
2. Fatty fish such as salmon, mackerel, tuna, sardines, herring
3. Vitamin D-fortified milk and cereal
4. Eggs
Functions
Taking the proper amount of vitamin D
may help prevent several serious health conditions. These conditions
include:
1. Osteoporosis - Vitamin D helps your body absorb and use
calcium, which you need for strong bones. Getting enough vitamin D
throughout your life is important, since most bone is formed when you
are young. For post-menopausal women who are at higher risk of
osteoporosis, taking vitamin D along with calcium supplements can
reduce the rate of bone loss, help prevent osteoporosis, and may
reduce the risk of fractures.
2. Other Bone Disorders - Vitamin D protects against rickets
and osteomalacia, softening of the bones in adults. Seniors who live
in northern areas and people who do not get direct sunlight for at
least 45 minutes per week should make sure they get enough vitamin D
through fortified milk and dairy products. Or, they can take a
vitamin D supplement or a multivitamin with vitamin D.
3. Prevention of Falls - People who have low levels of vitamin
D are at greater risk of falling, and studies have found that taking
a vitamin D supplement (700 - 1000 IU daily) may reduce that risk.
In seniors, vitamin D may reduce falls by 22%.
4. Parathyroid Problems - The four parathyroid glands are
located in the neck. They make parathyroid hormone (PTH), which helps
the body store and use calcium and phosphorus. Vitamin D is often
used to treat disorders of the parathyroid gland.
5. High Blood Pressure (Hypertension) - People with low levels
of vitamin D seem to have a high risk of developing high blood
pressure than those with higher levels of vitamin D. However,
there's no proof that low levels of vitamin D cause high blood
pressure in healthy people. Evidence about vitamin D and blood
pressure has been mixed.
6. Cancer - There is some evidence that getting enough vitamin
D may lower your risk of certain cancers, especially of the colon,
breast, prostate, skin, and pancreas. This evidence is based mostly
on studies of large groups of people, population studies, and doesn't
prove a connection between taking vitamin D and lowering your cancer
risk. Some research suggests that postmenopausal women who take calcium
and vitamin D supplements may have a lower risk of developing cancer
of any kind compared to those who don' t take these supplements.
7. Seasonal Affective Disorder (SAD) - SAD is a type of
depression that happens during the winter months, when there's not
much sunlight. It's often treated with photo (light) therapy. A few
studies suggest that the mood of people with SAD improves when they
take vitamin D. Talk to your doctor about whether vitamin D might
help your treatment for SAD.
8. Diabetes - Studies find that people who have lower levels
of vitamin D are more likely to develop type 2 diabetes than people
who have higher levels of vitamin D. But there is no evidence that
taking vitamin D can help prevent or treat type 2 diabetes. One
study found that giving infants doses of 2,000 IU per day of vitamin
D during the first year of life may help protect them from developing
type 1 diabetes when they are older.
9. Heart Disease - Studies suggest that people with low
levels of vitamin D have a greater risk of developing heart disease,
including heart attack, stroke, and heart failure compared to people
with higher levels of vitamin D. Low levels of vitamin D may
increase the risk of calcium build-up in the arteries. Calcium
build-up is part of the plaque that forms in arteries when you have
atherosclerosis and can lead to a heart attack or stroke.
10. Multiple Sclerosis (MS) - Studies have found that women
who take at least 400 IU of vitamin D daily lower their risk of
developing MS. And higher levels of vitamin D in the blood seem to
be associated with a lower risk of developing MS in white men and
women, although the same may not be true of African American and
Hispanic men and women. However, this does not mean that vitamin D
supplements will help prevent or treat MS in people.
11. Obesity - Studies have found that people who have lower
levels of vitamin D are more likely to be obese compared to people
with higher levels of vitamin D. One high-quality study also found
that postmenopausal women who took 400 IU vitamin D plus 1,000 mg
calcium daily for 3 years were less likely to gain weight than those
who took placebo, although the weight difference was small. Women who
were not getting enough calcium to start with (less than 1,200 mg per
day) saw the most benefit.
12. Overall Mortality - Studies suggest that people with lower
levels of vitamin D have a higher risk of dying from any cause.
Precautions
Because of the potential for side
effects and interactions with medications, you should take dietary
supplements only under the supervision of a knowledgeable health care
provider.
Taking too much vitamin D can cause
several side effects. However, scientists don' t all agree on how
much is too much. The National Institutes of Health has set the
maximum tolerable upper limit at 1,000 IU daily for infants 0 - 6
months, 1,500 IU daily for infants 6 months to one year, 2,500 IU
daily for children 1 - 3 years, 3,000 IU daily for children 4 - 8
years, and 4,000 IU daily for anyone over 9. Ask your doctor to
determine the right dose for you or your child.
Side effects may include:
-
Being very thirsty
-
Metal taste in mouth
-
Poor appetite
-
Weight loss
- Bone pain
-
Tiredness
-
Sore eyes
-
Itchy skin
-
Vomiting
- Diarrhea
-
Constipation
-
A frequent need to urinate
-
Muscle problems
You cannot get too much vitamin D from
sunlight, and it would be very hard to get too much from food.
Generally, too much vitamin D is a result of taking supplements in
too high a dose.
People with the following conditions
should be careful when considering taking vitamin D supplements:
High blood calcium or
phosphorus levels
Heart problems
Kidney disease
Sarcoidosis
Tuberculosis
Possible Interactions
If you are currently being treated with
any of the following medications, you should not use vitamin D
supplements without first talking to your health care provider.
Atorvastatin (Lipitor) -- Taking
vitamin D may reduce the amount of Lipitor absorbed by the body,
making it less effective. If you take Lipitor or any statin (drugs
used to lower cholesterol), ask your doctor before taking vitamin D.
Calcipotriene (Dovonex) -- It's
possible that taking vitamin D supplements and using calcipotriene, a
medication applied to the skin for psoriasis, could cause calcium
levels to get dangerously high in the blood.
Calcium channel blockers --
Vitamin D may interfere with these medications, used to treat high
blood pressure and heart conditions. If you take any of these
medications, do not take vitamin D without first asking your doctor.
Calcium channel blockers include:
Nifedipine (Procardia)
Verapamil (Calan)
Nicardipine (Cardene)
DiltiaZem (Cardizem, Dilacor)
Amlodipine (Norvasc)
Corticosteroids (prednisone) --
Taking corticosteroids long-term can cause bone loss, leading to
osteoporosis. Supplements of calcium and vitamin D can help maintain
bone strength. If you take corticosteroids for 6 months or more, ask
your doctor about taking a calcium and vitamin D supplement.
Digoxin (Lanoxin) -- a
medication used to treat irregular heart rhythms. Taking vitamin D if
you take digoxin may cause levels of calcium to get dangerously high
in the blood.
These drugs may raise the amount of
vitamin D in the blood:
Estrogen -- Hormone replacement
therapy with estrogen seems to raise vitamin D levels in the blood,
which may have a positive effect on calcium and bone strength. In
addition, taking vitamin D supplements along with estrogen
replacement therapy (ERT) increases bone mass more than ERT alone.
However, that may not be true if you also take progesterone.
Isoniazid (INH) -- a medication
used to treat tuberculosis.
Thiazide -- A diuretic or water
pill that helps your body get rid of too much fluid. It can increase
vitamin D activity and lead to high calcium levels in the blood.
Vitamin D levels may be lowered by
the following medications. If you take any of these medications,
ask your doctor if you need more vitamin D:
Antacids -- Taking certain
antacids for long periods of time may alter the levels, metabolism,
and availability of vitamin D.
Anti-seizure medications --
these medications include:
Phenobarbital
Phenytoin (Dilantin)
Primidone (Mysoline)
Valproic acid (Depakote)
Bile acid sequestrants -- used
to lower cholesterol. These medications include:
Cholestyramine (Questran,
Prevalite)
Cholestipol (Colestid)
Rifampin -- used to treat
tuberculosis
Mineral oil -- Mineral oil also
interferes with absorption of vitamin D.
Orlistat (Alli) -- a medication
used for weight loss that prevents your body for absorbing fat.
Because of how it works, orlistat may also prevent the absorption of
fat-soluble vitamins such as vitamin D. Doctors who prescribe
orlistat tell their patients to take a multivitamin with fat-soluble
vitamins.