If you are in the elderly group like I
am and over the age of 64, you are being discriminated against. Yes,
and this is because of our age and for other reasons. This arbitrary
age distinction is made to avoid the elderly that may have more than
one chronic disease and have other medical problems. I will quote
my blog here which did include ages up to 75.
“One statement that seems to sum
up how researchers feel about the elderly is this. Finally, we did
not recruit adults aged 76 years and greater because these
individuals may present with unique clinical (e.g., comorbidity,
complications) and functional (e.g., impairment, disability)
challenges that require special attention. For example, older
diabetes patients are at greater risk for several geriatric
syndromes, including depression, cognitive impairment, injurious
falls, neuropathic pain, and urinary incontinence. These syndromes
can have a deleterious effect on diabetes self-care, health status,
and quality of life. Thus, the value of group versus individual
diabetes education needs to be evaluated in the age 76 and up
population. Importantly, future diabetes behavioral interventions
need to address changes in older adult functional, cognitive, and
psychosocial states and how best to assess and address these
factors.”
This is still very discriminatory and
shows why most researchers will not include them in most studies.
Fortunately, this study was positive for showing that the elderly can
benefit from group education. However, even with this outcome, our
understanding of geriatric diabetes is still not enhanced and we
still need more research on geriatric diabetes. This is because over
half of those with type 2 diabetes are over the age of 65.
A study in the Journal of the American
Geriatrics Society shows that things are not changing and
discrimination still prevails. This link will only take you to the
abstract, but it still says a lot.
The information in this blog is
important enough to quote. “The authors analyzed 440 protocols
of ongoing studies of type 2 diabetes. The findings are very
discouraging:
- 66% of studies excluded subjects using an arbitrary upper
age limit. Upper age limits are almost never justified. Even
when drugs are tested in mostly younger patients, they get heavily
marketed and used by older patients
- 77% of studies excluded subjects with comorbid
conditions--diseases in addition to diabetes. An acceptable
justification for exclusions based on comorbidity was provided less
than a 25% of the time. The vast majority of patients with diabetes
have comorbidity. It is crucial we learn how comorbidity impacts
the outcomes of treatment. Exclusions based on comorbidity often
makes the real world application of diabetes studies
uninterpretable.
- Regulatory agencies such as the FDA must develop clear
regulations that demand drugs will be tested in the patients that
actually will use them before they are allowed to be widely used
- Funders such as the NIH should stop turning a blind eye
towards ageism in clinical research
- Human subjects committees should avoid approving protocols
that needlessly exclude older subjects
- Older patients and those who care about them should insist
that research that improves their care is a major societal need”
In addition, since the elderly is the
largest group being prescribed the diabetes drugs, we need the
studies for treatment guidelines and to show how the different drugs impact the problems older persons
care about such as functional impairment, cognitive function, falls,
and incontinence. Researchers need to make changes in the
procedures they use for studies and the above players need to step up
and take responsibility.
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