The study's authors note that statins
are prescribed under medical control, and blood tests are
periodically performed so that statin use can be stopped as soon as
abnormal results are identified. On the contrary, red yeast rice (RYR) is used as self-prescription, without medical advice and
monitoring, so patients risk experiencing toxic effects that may go
unnoticed.
RYR is contained in dietary supplements
that are often used by patients with high cholesterol, and it is
often proposed as an alternative therapy in those who experience side
effects from statins. A new study found that it is not a good choice
for statin-intolerant patients: RYR was linked with muscle and liver
injury, which can also occur with statin use.
The beneficial effects of RYR are
ascribed to monacolins, which are chemically related to statins.
"The proportion of serious reports
(27%), the relatively rapid time to onset and the lack of concomitant
drugs and/or predisposing medications in several cases warrants
regulatory consideration and call for: 1) continuous monitoring of
"natural" dietary supplements safety through spontaneous
reports; 2) appropriate information to clinicians and consumers, who
should timely submit suspect reports to regulatory Agencies,"
wrote the authors of the British Journal of Clinical Pharmacology
study.
This study tool place in Italy.
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