I like the opening statement from AnhInternational, which states - “If you hadn’t noticed that the
statin bubble had burst, you were probably suffering a statin-induced
fuzzy head and hadn’t managed to stay up with breaking news.”
Over the past months a flurry of
long-term studies have been emerging, driving the last nails into the
coffin of one of the most profitable drug classes the pharmaceutical
industry has yet seen. Or so it might seem.
Statins are prescribed for the purpose of reducing cholesterol levels, which have long been viewed as a major risk factor for heart disease. How many people know the long-term risks (or benefits, or otherwise) of statins before they take them?
Statins are prescribed for the purpose of reducing cholesterol levels, which have long been viewed as a major risk factor for heart disease. How many people know the long-term risks (or benefits, or otherwise) of statins before they take them?
While the scientific edifice for this
assertion may largely have collapsed, major health authorities like
the US National Institutes of Health (NIH) are much slower to retract
their argument that high cholesterol in the bloodstream leads to
clogging up of arteries and increased heart attack risk. This
misinformed and greatly over-simplified view results in
over-prescription of statins, with the US being the number one
prescribing nation in the world and the UK the second biggest. Over
a million statin prescriptions are filled each week in the UK.
If they were talking about more
sensitive measurements of C-Reactive Protein (CRP), sub-clinical
low-grade inflammation, apolipoproteins profiles or oxidized
fractions of very low-density lipoprotein (ox-VLDL), that would be an
entirely different issue. But only doctors and practitioners really
prepared to look at the totality of evidence, including emerging
evidence, are presently using comprehensive cardiovascular risk
profiles including some of these emerging markers. To top if off
though, statin drugs themselves actually cause atherosclerosis and
heart disease…
Big Pharma, and its servants in health
and regulatory authorities, don’t give up so easily. Even the US
FDA, while being forced to admit and communicate more evidence of
harm, still argues that purported benefits in reducing heart disease
outweigh risks, be these kidney, brain, muscle or eye damage, or
increased type 2 diabetes incidence. More than that, seemingly
outlandish new claims for other ‘spin-off’ benefits keep
emerging, helping offset the bad publicity about side effects.
Among the headlines generated recently
are:
- “Statins can halve patients’ risk of dying from cancer”. These data were based on observational studies, they were publicized at a conference, generated headlines globally—and have since been contested.
- “Statins may reduce dementia by a third”
- “Double duty drug: statins may fight MS”
- “Statins could reverse most common form of blindness”
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