September 24, 2016

Silver Nanoparticles Help Prevent Foot Amputations

One of the major complications of diabetes is the appearance of wounds in the lower extremities that do not heal properly. In this situation, a group of researchers from the UNAM created a solution made of silver nanoparticles, which in clinical trials has healed ulcers in people with diabetic foot, avoiding the amputation of more than 90 percent of patients treated.

"The ulcer is an open wound, susceptible to infection by bacteria and fungi that generate inflammation, which prevents the injury from healing; however, in applying the silver nanoparticles an antibacterial effect that contributes to create healthy tissue," said Dr. Karla Oyuky Juárez Moreno, researcher at the Center for Nanoscience and Nanotechnology (CNyN) located in Ensenada, Baja California.

The development, called Nagsil Dermo® works in three months to heal diabetic foot ulcers. First, a doctor should remove dead tissue and then apply the solution spray. Dr. Juarez Moreno stressed that for an effective treatment this must be applied daily and be supervised by specialists.

According to data from the Ministry of Health, seven out of ten cases of diabetic foot ulcers result in amputation and the World Health Organization (WHO) reports that due to the lack of control of blood glucose, between 40 and 85 percent of patients lose a limb.

The solution applied in patients that had a treatment with antibiotic during more than six months but don't see improvements, some had the diagnostic of amputation. "With our development report of a cicatrization, the time depends on the ulcer.

Four types of vascular damage and tissue exist. "Those who have the levels one, two and three relieved in less of six months, therefore those which have the level four where the amputation is inevitable, in this cases there is a ten percent of success," detailed Dr. Juarez Moreno.

The group of scientists has implemented innovation in private clinics and health sector, including ISSSTECALI hospitals and General de Rosarito, both located in Baja California, in the latter over a hundred cases were treated and 94 percent saved their limbs.

At national level there are 60 patients who have saved their limbs from the use of Nagsil Dermo®, an economic cosmetic product whose price is 550 pesos for a bottle of 50 milliliters, which is marketed through Bionag, a spin off created by the Network Conacyt located in Tijuana.

Scientific and technological development has international certificates toxicity committees supporting the safety of silver nanoparticles for use as a cosmetic in humans. They are also coated with a polymer that provides stability for more than two years.

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