Showing posts with label Choline. Show all posts
Showing posts with label Choline. Show all posts

April 8, 2016

Are You Getting These Nutrients? - Part 12

Choline

I would urge you to read the first blog above as to write more would duplicate that blog.

With that, I will move to the next nutrient – Niacin or Vitamin B3.

Vitamin B3 is one of eight B vitamins. It is also known as niacin (nicotinic acid) and has 2 other forms, niacinamide (nicotinamide) and inositol hexanicotinate, which have different effects from niacin.

All B vitamins help the body convert food (carbohydrates) into fuel (glucose), which the body uses to produce energy. These B vitamins often referred to as B-complex vitamins, also help the body use fats and protein. B-complex vitamins are needed for a healthy liver, healthy skin, hair, and eyes, and to help the nervous system function properly.

Niacin also helps the body make various sex and stress-related hormones in the adrenal glands and other parts of the body. Niacin helps improve circulation, and it has been shown to suppress inflammation.

You can meet all of your body's needs for B3 through diet. It is rare for anyone in the developed world to have a B3 deficiency. In the U.S., alcoholism is the main cause of vitamin B3 deficiency.

Symptoms of mild B3 deficiency include – indigestion, fatigue, canker sores, vomiting, poor circulation, and depression. Severe deficiency can cause a condition known as pellagra. Pellagra is characterized by cracked, scaly skin, dementia, and diarrhea. It is generally treated with a nutritionally balanced diet and niacin supplements. Niacin deficiency also causes burning in the mouth and a swollen, bright red tongue.

The best food sources of vitamin B3 are – beets, brewer's yeast, beef liver, beef kidney, fish, salmon, swordfish, tuna, sunflower seeds, and peanuts. Bread and cereals are usually fortified with niacin. In addition, foods that contain tryptophan, an amino acid the body coverts into niacin include poultry, red meat, eggs, and dairy products.

Vitamin B3 is available in several different supplement forms:
  • Niacinamide
  • Niacin
  • Inositol hexaniacinate.

Niacin is available as a tablet or capsule in both regular and timed-release forms. The timed-release tablets and capsules may have fewer side effects than regular niacin. However, the timed-release versions are more likely to cause liver damage. Regardless of which form of niacin you are using, doctors recommend periodic liver function tests when using high doses (above 100 mg per day) of niacin.

Generally, high doses of niacin are used to control specific diseases. Such high doses must be prescribed by a doctor who will increase the amount of niacin slowly, over the course of 4 to 6 weeks. Take niacin with meals to avoid stomach irritation.

Daily recommendations for niacin in the diet of healthy individuals are:
Adult
  • Men, 19 years and older: 16 mg (RDA)
  • Women, 19 years and older: 14 mg (RDA)
  • Pregnant women: 18 mg (RDA)
  • Breastfeeding women: 17 mg (RDA)

Because of the potential for side effects and interactions with medications, you should take dietary supplements only under the supervision of a knowledgeable doctor. Side effects may include diarrhea, headache, stomach discomfort, and bloating.

High doses (50 mg or more) of niacin can cause side effects. The most common side effect is called "niacin flush," which is a burning, tingling sensation in the face and chest, and red or flushed skin. Take an aspirin 30 minutes before the niacin may help reduce this symptom.

At very high doses, used to lower cholesterol and treat other conditions, liver damage and stomach ulcers can occur. Your doctor will regularly check your liver function through a blood test.

People with a history of liver disease, kidney disease, or stomach ulcers should not take niacin supplements. Those with diabetes or gallbladder disease should do so only under the close supervision of their doctors.

Stop taking niacin or niacinamide at least 2 weeks before a scheduled surgery.
Niacin and niacinamide may make allergies worse by increasing histamine.

People with low blood pressure should not take niacin or niacinamide because they may cause a dangerous drop in blood pressure. DO NOT take niacin if you have a history of gout.

People with coronary artery disease or unstable angina should not take niacin without their doctor's supervision, as large doses can raise the risk of heart rhythm problems.

Taking any one of the B vitamins for a long period of time can result in an imbalance of other important B vitamins. For this reason, you may want to take a B-complex vitamin, which includes all the B vitamins.

August 15, 2012

Nutrients – Choline

Choline

Overview
Choline is similar to the B vitamins and is made in the liver. Choline is not strictly defined as a vitamin, but it is an essential nutrient. Choline is used for liver disease, including chronic hepatitis and cirrhosis. It is also used for depression, memory loss, Alzheimer's disease and dementia, Huntington's chorea, Tourette's disease, a brain disorder called cerebellar ataxia, certain types of seizures, and a mental condition called schizophrenia.

Choline is synthesized by the human body in small amounts, but still must be consumed to have an adequate supply. Athletes use it for bodybuilding and delaying fatigue in endurance sports. Choline is taken by pregnant women to prevent neural tube defects in their babies and it is used as a supplement in infant formulas. Other uses include preventing cancer, lowering cholesterol, and controlling asthma.

Deficiency Signs and Symptoms
The most common signs of choline deficiencies are fatty liver and hemorrhagic kidney necrosis. Dietary intake of a choline full diet can reduce the severity of the deficiency. Choline deficiency may play a role in liver disease, atherosclerosis, and possibly neurological disorders. One symptom of choline deficiency is an elevated level of the liver enzyme ALT.

Tests
There are a few tests, but none that I can find that your doctor may use. The doctor may know which tests are available to use. One that is mentioned is the platinochloride test for choline in human blood; however, this is not listed when looking for choline tests that I researched.

Recommended Daily Allowance
Adequate Intake (AI) for Choline
Life stage
Age
Males
(mg/day)
Females
(mg/day)
Infants
0-6 months
125
125
Infants
7-12 months
150
150
Children
1-3 years
200
200
Children
4-8 years
250
250
Children
9-13 years
375
375
Adolescents
14-18 years
550
400
Adults
19 years and older
550
425
Pregnancy
All ages
-
450
Breast-feeding
All ages
-
550

Tolerable Upper Intake Level (UL) for Choline
Age group
UL (g/day)
Infants 0-12 months
Not possible to establish*
Children 1-8 years
1.0
Children 9-13 years
2.0
Adolescents 14-18 years
3.0
Adults 19 years and older
3.5

Notice that the top chart is in milligrams and the bottom chart is in grams.

Function
Choline is similar to a B vitamin. It is used in many chemical reactions in the body. Choline seems to be an important element in the nervous system. In asthma, choline might help decrease swelling and inflammation.

Food Sources
It is in foods such as liver, muscle meats, fish, nuts, beans, peas, spinach, wheat germ, and eggs. It is generally recognized that it is important to get dietary choline from these foods as well.

Animal and plant food
Choline (mg)
Calories
5 ounces (142 g) raw beef liver
473
192
Large hardboiled egg
113
78
Half a pound (227 g) cod fish
190
238
Half a pound of chicken
150
543
Quart of milk, 1% fat
173
410
A gram soy lecithin
30 approx.
8
100 grams of Soybeans dry
116
268
A pound (454 grams) of cauliflower
177
104
A pound of spinach
113
154
A cup of wheat germ
202
432
Two cups (0.47 liters) firm tofu
142
353
Two cups of cooked kidney beans
108
450
A cup of uncooked quinoa
119
626
A cup of uncooked amaranth
135
716
A grapefruit
19
103
3 cups (710 cc) cooked brown rice
54
649
A cup (146 g) of peanuts
77
828
A cup (143 g) of almonds
74
822

Precautions
There is some concern that increasing dietary choline intake might increase the risk of cancer of the colon and rectum. One study found that women eating a diet that contains a lot of choline have an increased the risk of colon cancer. However, more research is still needed to determine the effects of diet on colon cancer.

Choline is seems to be safe when taken by mouth and used appropriately. Doses up to 3 grams daily for pregnant and breast-feeding women up to 18 years of age, and 3.5 grams daily for women 19 years and older are not likely to cause unwanted side effects. There isn’t enough information available about the safety of choline used in higher doses in pregnant or lactating women. It’s best to stick to recommended doses.

Possible Interactions
High doses (10 to 16 grams/day) of choline have been associated with a fishy body odor, vomiting, salivation, and increased sweating. The fishy body odor results from excessive production and excretion of trimethylamine, a metabolite of choline. Taking large doses of choline in the form of phosphatidylcholine (lecithin) does not generally result in fishy body odor, because its metabolism results in little trimethylamine. A dose of 7.5 grams of choline/day was found to have a slight blood pressure lowering (hypotensive) effect, which could result in dizziness or fainting. Choline magnesium trisalicylate at doses of 3 grams/day has resulted in impaired liver function, generalized itching, and ringing of the ears (tinnitus). However, it is likely that these effects were a result of the salicylate, rather than the choline in the preparation.

Little is known regarding the amount of dietary choline most likely to promote optimum health or prevent chronic disease in older adults. At present, there is no evidence to support a different intake of choline from that of younger adults (550 mg/day for men and 425 mg/day for women).

Methotrexate, a medication used in the treatment of cancer, psoriasis, and rheumatoid arthritis, inhibits the enzyme dihydrofolate reductase and therefore limits the availability of methyl groups donated from folate derivatives. Rats given methotrexate have shown evidence of diminished nutritional status of choline, including fatty liver, which can be reversed by choline supplementation. Thus, individuals taking methotrexate may have an increased choline requirement.

July 28, 2012

Introduction to Series on Vitamins and Minerals


Many of us are deficient in certain nutrients and our doctors do not or will not test us for deficiencies as we age. Some of us do have sufficient quantities in our diets and then take supplements, which may give us an oversupply. I will give the name of the test when it is available. Your doctor should test for all of these (that have testing available) before you run out and buy supplements. You may not need them because you are already obtaining sufficient intake from your diet. If you have a doctor that will not test because you should be eating foods with sufficient nutrients, then you will have a decision to make about retaining your current doctor.

I realize that many of you may be aware of them, but it never hurts to review them. In the coming blogs I will cover iodine, selenium, choline, manganese, magnesium, potassium, Vitamin D, Vitamin K, and Vitamin B12. These may not be what you would think is needed for those of us with diabetes; however, they are still important. If you would like more detailed information, please read the links supplied with each blog as there may be several links. Some are water-soluble and others are fat-soluble. Vitamin D is neither as it is correctly a hormone. This will not change because of acceptance.

I would be remiss if I did not give you a warning about not overcompensating and ingesting too much of some of these nutrients as there are some medical concerns with toxicity and conflicts with certain prescription medications. More is often not better and can be fatal with some supplements. I will give warnings where they apply.

When there is a list of foods that may give you sufficient supply of a nutrient, they will be listed.

Since most of these vitamins and minerals have recommended daily allowances (RDAs) that vary by age, the entire table will be given. Some sources list only the adult RDAs and I prefer to give you the full list.

Please refer back to this blog if you question something and I will update this blog with each blog as I publish it. Some of my blogs will refer to my other blogs, as the nutrients can be essential for the same thing. Example - iodine and selenium both are essential for the thyroid gland to work properly. There may be others, but as of yet, I am not into research for each of them. I had intended to put two or three nutrients in a single blog, but with all that I am discovering, this would make the blog too long and essential points less obvious.

Vitamin K